Recovery Peptides Anti-aging Immune Modulators Growth Factors Gastrointestinal Peptides Under research

BPC-157

Also known as: Body Protection Compound 157, PL-10

BPC-157 is a synthetic 15-amino acid pentadecapeptide derived from the human gastric Body Protection Compound (BPC). Extensively studied in animal models for its regenerative, gastroprotective, and anti-inflammatory properties. One of the most popular research peptides in the sports and regenerative medicine field.

Mechanism of action

It acts through multiple signaling pathways:

Upregulation of growth factors: VEGF (angiogenesis), EGF and FGF
Activation of the nitric oxide (NO) pathway, promoting vasodilation and tissue perfusion
Modulation of dopaminergic and serotonergic systems
Inhibition of pro-inflammatory mediators (TNF-α, IL-6)
Stimulation of fibroblast proliferation and collagen synthesis

Uses & indications

Soft tissue healing: Tendons, ligaments (Achilles tendon rupture, rotator cuff injuries)
Muscle regeneration after injury or surgery
Gastroprotection: Gastric ulcers, irritable bowel syndrome, inflammatory bowel disease
Neuroprotection: Brain and spinal cord injuries (animal studies)
Scar tissue reduction

Effects

Beneficial (in animal models): Accelerated tendon and ligament healing, significant reduction in inflammatory markers, documented gastroprotective properties, potential neuroprotective effects.

Reported adverse effects: Minimal in animal studies. No significant systemic toxicity at standard doses. In humans: data limited to anecdotal reports; mild nausea in some cases.

Considerations & contraindications

Not approved by FDA or EMA for human therapeutic use
All solid clinical evidence comes from animal models
Human trials are scarce and of low methodological quality
Do not use during pregnancy or breastfeeding
Consult a medical professional before any use

Regulatory approval

Research peptide. Not approved for clinical use in any country. Limited Phase I/II human trials. Pliva (Croatia) conducted preliminary studies.

Dosage

Research use: 1–10 μg/kg. Anecdotal human exploratory dose: 200–500 μg/day (sc or im). Typical cycles: 4–12 weeks.

Storage

Lyophilized: store at −20°C, protect from light and moisture. Reconstituted: 4°C, use within 4–6 weeks. Avoid freeze-thaw cycles.

Technical data

Regulatory status Under research

Molecular weight 1419.53 Da

Half-life ~4 h (sistémica) / ~16 h (oral)

Administration routes Subcutánea, intramuscular, oral, intranasal