Hormonal Modulators Peptide Hormones Approved

Gonadorelina

Also known as: GnRH, Factrel

Gonadorelin (GnRH) is the synthetic version of the body's natural Gonadotropin-Releasing Hormone. It is produced in the hypothalamus and travels to the pituitary gland to instruct it to release LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone). These messengers are responsible for maintaining fertility, sperm and egg production, and testosterone/estrogen synthesis.

Mechanism of action

Directly couples to the GnRH receptor in the gonadotrope cells of the anterior pituitary.
Forces the pituitary to release stored LH and FSH into the blood.
Must be secreted in natural pulses (every 1-2 hours in men, variant in women) to work; continuous exposure to GnRH causes total inhibition (medical castration) instead of stimulation.

Uses & indications

Testicular function recovery (TRT): In the sports community to prevent testicular shrinkage, it is used as a replacement for hCG, directly stimulating the axis from higher up.
Infertility: Treatment of hypogonadotropic hypogonadism or amenorrhea in women using pulsatile infusion pumps.

Effects

Preservation of fertility and testicular volume in individuals on external testosterone therapy, reactivation of the endogenous axis.

Considerations & contraindications

Unlike HCG (which mimics LH directly), Gonadorelin mimics brain GnRH, thus requiring a functional pituitary to be effective.
Very high risk of desensitization if used in incorrect doses; the pituitary gland will stop responding and all hormone production will halt.

Regulatory approval

Medically approved as Factrel / Lutrepulse.

Dosage

For preventing testicular atrophy, athletes usually use micro-doses (e.g., 100mcg) twice a week or frequently, but practices vary widely due to the difficulty of mimicking pulses.

Storage

Lyophilized at -20°C.

Technical data

Regulatory status Approved

Molecular weight 1182.3 Da

Half-life Menos de 10-20 minutos

Administration routes Subcutánea, Intravenosa (bomba pulsátil)