Mitochondrial Peptides Immune Modulators Under research

Mitocriptide

Also known as: Mitocryptide-1 (MCT-1)

Mitocryptide-1 (MCT-1) is a very specific endogenous mitochondria-derived peptide, isolated as the first peptide encoded in the mitochondrial cytochrome b gene that attracts and activates neutrophils, functioning as a direct link between mitochondrial stress, local inflammatory response, and healing processes.

Mechanism of action

Released during severe mitochondrial stress or cell damage.
Acts as a chemoattractant, signaling directly to immune system neutrophils to flock to the site of damage to repair the tissue.
Unlike anti-inflammatory peptides (like KPV), MCT-1 orchestrates a beneficial and rapid localized immune response, crucial in the early phases of tissue trauma.

Uses & indications

Accelerated healing: Stimulates the repair of acute wounds by coordinating the initial inflammatory phase of wound closure.
Diagnostic monitoring: Its levels act as a biomarker for muscle injury or traumatic stress.

Effects

Rapid immune-mediated clearance of necrotic tissue and an accelerated transition to the post-trauma regenerative phase.

Considerations & contraindications

Purely research use for burns and deep trauma repair. Not routinely used for hypertrophy or anti-aging.

Regulatory approval

Novel; restricted to academic and experimental settings.

Dosage

Laboratory use; micromolar topical concentrations at wound sites.

Storage

Lyophilized at -20°C.

Technical data

Regulatory status Under research

Molecular weight Aprox 1600 Da

Half-life Cortísima, acción local paracrina

Administration routes Tópica o inyección perilesional