Anti-aging Neuropeptides Mitochondrial Peptides Under research

MTRNR2L1

Also known as: Humanin-like 1, HN1

MTRNR2L1 (Humanin-like 1) is a pseudogene and the peptide it encodes, which shares immense structural and functional similarity with Humanin. It is part of a family of "humanin-like" molecules encoded in the cellular nucleus but of mitochondrial descent. It shares the highly potent neuroprotective and anti-sclerotic profile of the original humanin.

Mechanism of action

Inhibits apoptotic pathways (cell death) by interacting with intracellular regulatory proteins similar to humanin.
Positively regulates the survival of cardiomyocytes and cerebral Purkinje cells.

Uses & indications

General ischemic protection: Potential applications in ischemic heart disease and stroke.

Effects

Dramatic increase in cell viability following oxygen deprivation and ischemia, mitigation of endothelial senescence.

Considerations & contraindications

Usually investigated in parallel or cross-referenced with Humanin and MOTS-c due to their synergy.

Regulatory approval

Basic research and animal models.

Dosage

No standard human dosage established. Variable animal experiment doses.

Storage

Lyophilized at -20°C.

Technical data

Regulatory status Under research

Molecular weight ~2700 Da

Half-life Corto

Administration routes Subcutánea, Intravenosa