Recovery Peptides Anti-aging Growth Factors Under research

PEG-MGF

Also known as: Pegylated Mechano Growth Factor

PEG-MGF is Mechano Growth Factor (MGF) that has had a polyethylene glycol molecule attached (pegylation). Standard MGF has a half-life of mere minutes and must be injected locally, whereas the addition of the PEG group protects the peptide from enzymatic degradation, extending its half-life to several days and allowing for continuous systemic muscle growth and recovery effects.

Mechanism of action

Like MGF, it promotes the proliferation of muscle satellite cells.
Pegylation acts as an inert shield preventing renal excretion and protease degradation in plasma.
It circulates bound to PEG until it reaches the muscle or tissue receptor site where it exerts its long-term regenerative action.

Uses & indications

General systemic recovery: Ideal for rest days.
Growth of new muscle fibers: Muscle hyperplasia.
Neuroprotection: Investigated for positive effects on motor neurons.

Effects

Improved nitrogen retention, greater protein synthesis, increased muscle density, long-lasting systemic regenerative effects.

Considerations & contraindications

Unlike normal MGF, it is administered subcutaneously on rest days, not post-training, to avoid interfering with endogenous natural MGF release.
Requires limited cycles due to possible receptor desensitization.

Regulatory approval

Not approved for human use.

Dosage

Usually 200-400mcg twice per week (on rest days).

Storage

Lyophilized at -20°C. Reconstituted at 4°C and protect from light. The PEG group gives it greater stability in water.

Technical data

Regulatory status Under research

Molecular weight ~2888 Da (péptido) + masa del PEG

Half-life 48 - 72 horas

Administration routes Subcutánea (acción sistémica)