Immune Modulators Desconocido

Thymosin Alpha-1

Also known as: TA1, Zadaxin, Thymalfasin

Thymosin Alpha-1 (TA1) is a naturally occurring peptide produced by the thymus gland. It plays a fundamental role in regulating and modulating the immune system, stimulating T cells to fight infections and diseases. It is used clinically in several countries to treat chronic viral infections like Hepatitis B and C, and as an immune adjuvant in cancer therapies.

Mechanism of action

Enhances the maturation of T cells (CD4+ and CD8+).
Increases the production of beneficial cytokines such as IFN-gamma, IL-2, and IL-3.
Activates natural killer (NK) cells and improves antigen presentation.
Modulates the immune system, returning it to homeostasis without overstimulating it.

Uses & indications

Viral infections: Hepatitis, HIV, respiratory infections.
Autoimmune diseases: Chronic Lyme disease, chronic fatigue syndrome.
Immunodeficiency: General immune booster and vaccine adjuvant.

Effects

Robust restoration of immune function, improved resistance to recurrent infections, reduction of symptoms in autoimmune and inflammatory conditions.

Considerations & contraindications

Excellent safety profile documented over decades of clinical use.
Approved in numerous countries under the name Zadaxin.

Regulatory approval

Approved in over 30 countries (Zadaxin) for Hepatitis B, C, and as a vaccine adjuvant. Not approved by the FDA in the US.

Dosage

Generally 1.6mg injected subcutaneously twice a week for a period of several weeks to months.

Storage

Lyophilized keep refrigerated or frozen. Reconstituted at 4°C and ideally use within a few weeks.

Technical data

Regulatory status Desconocido

Molecular weight 3108.3 Da

Half-life Aproximadamente 2 horas en plasma

Administration routes Subcutánea